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Ärzteinformationen Forschungsvorhaben - Studienprotokolle
letztes Update: 28.10.02
Die dem VDD bekannt gewordenen Forschungsvorhaben auf dem Gebiet der HBO und/oder verwandter Fachgebiete werden hier aufgeführt (sicher nicht vollständig - wir bitten ggf. um Information zur Ergänzung dieser Seite)
Studienprotokolle, die auf Europäischer Basis durch die EU Commission "Cooperation in Science and Technology" (COST B 14 = Hyperbare Medizin ) in Zusammenarbeit aller interessierten Länder (c 18 = mehr als EU Mitglieder !) erstellt wurden:
Hörsturz
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Hyperbarer Sauerstoff in der Frühbehandlung von Hörstürzen
Randomisierte, prospektive Studie der HBO-Therapie nach erfolgloser Vorbehandlung
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Power-Point Einführung in diese Studie
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Vereinbarung mit Behandlungszentren
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Patienteneinwilligung in die Studie
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Datenerfassungsformblätter
das zustimmende Votum der Ethikkommission der Bayerischen Landesärtzekammer liegt jetzt (28.10.02) vor, sodass die Studie unverzüglich beginnen kann.
Diabetisches Fußulcus
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Evaluation of Hyperbaric Oxygen Therapy in the treatment of diabetic foot lesion
A randomised controlled prospective study
Glioblastombehandlung
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Role of hyperbaric oxygen in enhancing radiosensitivity on glioblastoma multiforme
A randomised controlled prospective study
Osteointegrierte Implantate in Bestrahlungsregion
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OSSEOINTEGRATION IN IRRADIATED PATIENTS. ADJUNCTIVE HBO TO PREVENT IMPLANT FAILURES
CA-Rezidive im Kopf- Halsbereich
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Re-irradiation of recurrent squamous cell carcinoma of the head and neck (SCCHN) after HBO sensitization
UNDERSEA & HYPERBARIC MEDICAL SOCIETY, INC.
Undersea Medicine ... Hyperbaric Therapy
An international professional association serving the undersea and hyperbaric communities
Volume 30, Number I ISSN 0889-0242
2001 January/February
NIH GRANT FOR RESEARCH IN HYPERBARIC MEDICINE
Dr. Stephen Thom Receives 5-Year Research Grant
Lee J. Greenbaum, Jr.
Due by I March 2001
It is a surprise but also reassuring to know that the National Institutes of Health has begun to recognize the fact that hyperbaric oxygen therapy is indeed a viable therapy and should be included in the artnamentarium of medical treatments for a numher of illnesses. This recognition is now made evident through a major grant to one of our very own, a Society past president, Dr Stephen Thom at the University of Pennsylvani
The 5-year grant-1.5 million (US) dollars per year-will support a multidisciplinary effort to investigate the mechanisms of action, safety, and clinical efficacy of hyperbaric oxygen therapy (HBO,T). This program will consist of four research projects and three core projects. These projects will focus on the benefits of HBO,T in head and neck cancer patients who must undergo reconstructive surgery after radiation therapy. The common themes within the four research projects are the biology and clinical responses to elevations in ambient oxygen concentrations of head and neck tumors, endothelium, macrophages and neutrophils.
The first research project will attempt to develop a predictive model for surgical risk among patients requiring laryngectomy due to cancer, and then to validate the model and assess the efficacy of HBO-T for improving outcome.
The second project will evaluate the mechanism of angiogenesis resulting from HBO in irradiated mice and tumor xenograft growth responses. The stimulation of angiogenesis in irradiated tissue by HBO-T is hypothesized for both the first and second research projects. Hypovascularity and hypoxia in both research projects will be directly evaluated by histpathological analyses of biopsy samples and of oxygen-dependent binding to tissues of the nitroinidazole compound EF-5.
During the third research project, Dr. Thom will examine his hypothesis that the elevated pO, will reduce metastatic head and neck tumor cells and deter neutrophils from attaching to pulmonary endothelium.
The fourth project or study proposes that HBO-T increases the endogenous production of nitric oxide, a second messenger that, in turn, may play a role in many of the physiological responses studied in this program.
There are two important adjuncts to the program. First, the funding will provide $100,000 per year for pilot studies to be coordinated by the Administrative Core of the program. And second, funds will be provided to support two research fellows, beginning in year two. C3
